Tasks and Responsibilities:

Essential duties and responsibilities include the following. Other duties may be assigned.

• Demonstrates technical in vitro skills (proficiency performing in vitro cell culture, scale-up, banking and maintenance of frozen stocks)
• Demonstrates technical in vivo skills (proficiency in handling rodents, administering therapeutics via various routes, tumor implantation and measurement, blood collection, animal necropsy)
• Designs, plans, prioritizes, executes and interprets in vivo studies using skills focused on identifying candidate molecules and translational research within the area of oncology with minimal guidance
• Prepares formulation and dosing solutions
• Familiar with development and characterization of mouse models of cancer
• Experience with ex vivo assays (e.g. qPCR, western blot) and immunohistochemistry
• Works closely with DMPK, Biology, Translational Medicine, and Project teams to determine key pharmacology questions and seek solutions
• Collects, records and analyzes data in electronic notebook format using programs such as Microsoft Office Applications, Prism and Benchling
• Perform all duties in keeping with the Company's core values, policies and all applicable regulations.

Requirements:

• A M.Sc. with 2+ years or a B.Sc. with 5+ years life sciences experience with a strong focus on in vivo pharmacology/immunology in an industry setting
• Experience in utilizing preclinical cancer models (xenograft, syngeneic and PDX) and applied technologies enabling in vivo analyses
• Broad experience on generating in vivo pharmacology data to support the discovery and development of novel cancer therapeutics, including efficacy, tolerability, PK, PK/PD, and biomarker endpoints
• Understanding of key components and process of drug discovery, applied pharmacology and drug development
• Hands-on experience in relevant ex vivo experimental and molecular biology techniques such as cell culture, ELISA, qPCR, western blot, immunohistochemistry, flow cytometry and cell immunophenotyping
• Familiarity with the regulatory requirements to remain compliant with IACUC and AALAC regulations
• Ability to maintain proper scientific documentation associated with pharmacology studies in electronic lab notebooks, write technical reports and present summaries of research results
• Strong communication skills and ability to work effectively in a multidisciplinary team environment
• Highly collaborative, self-driven and detail-oriented individual