ORIC is a research-driven company dedicated to discovering and developing novel therapies that can Overcome Resistance In Cancer. Our collaborative, empowering culture gives scientists the authority, responsibility, and support to do cutting-edge work on therapies for treatment-resistant cancers. Our culture and values support our mission, provide a shared understanding of how we work together as a company and provide a clear sense of what is most important for us as an organization.
We are looking for a motivated and experienced researcher to join our In Vivo Pharmacology group. The individual will execute in vivo efficacy and PK/PD studies in support of ORIC’s drug development programs. Reports to the In Vivo Pharmacology group leader and collaborates extensively with DMPK and Biology teams.
Tasks and Responsibilities:
Other duties may be assigned.
- Demonstrates technical in vitro skills (proficiency performing in vitro cell culture, scale-up, banking and maintenance of frozen stocks)
- Demonstrates technical in vivo skills (proficiency in handling rodents, administering therapeutics via various routes, tumor implantation and measurement, blood collection, animal necropsy)
- Executes in vivo studies using skills focused on identifying candidate molecules and translational research within the area of oncology with guidance
- Prepares formulation and dosing solutions
- Collects, records and analyzes data in electronic notebook format using programs such as Microsoft Office Applications, Prism and Benchling
- Perform all duties in keeping with the Company's core values, policies and all applicable regulations.
- A B.Sc. in Biology, Pharmacology or related discipline with 1+ years life sciences experience with a strong focus on in vivo pharmacology in an industry setting
- Experience in utilizing preclinical cancer models (xenograft, syngeneic and PDX) and applied technologies enabling in vivo analyses
- Hands-on experience in relevant ex vivo experimental and molecular biology techniques such as cell culture, ELISA, qPCR, western blot, immunohistochemistry, flow cytometry and cell immunophenotyping is a plus
- Familiarity with the regulatory requirements to remain compliant with IACUC and AALAC regulations
- Ability to maintain proper scientific documentation associated with pharmacology studies in electronic lab notebooks, write technical reports and present summaries of research results
- Strong communication skills and ability to work effectively in a multidisciplinary team environment
- Highly collaborative, self-driven and detail-oriented individual
- Other duties may be assigned.