Sr. Research Associate/Scientist I, Structural Biology at Carmot Therapeutics
Berkeley, CA, US

Carmot Therapeutics, Inc., is a clinical-stage biotechnology company applying its proprietary drug discovery platform, Chemotype Evolution (CE), to discover and develop disease-modifying therapies in metabolic diseases and cancer. This position requires cross functional work within our biology, pharmacology, and chemistry teams. Our environment is exciting and fast paced, requiring you to be excellent at multitasking and easily adaptable to meet evolving goals. At Carmot we value diverse perspectives and encourage our scientists to contribute at multiple levels within the company, including strategic development.

Primary Responsibilities

  • Produce recombinant proteins in E. coli, insect and mammalian expression systems to support structural biology efforts and biophysical/ biochemical assays.
  • Perform crystallization screening and optimize conditions of co-crystallization of protein/ ligand complexes to produce high-quality crystals for X-ray diffraction.
  • Biochemical/biophysical assays as necessary to ensure protein activity

Required Qualifications

  • MS/PhD in biology, biophysics, biochemistry or related discipline with 2-3 years (MS) or 0-1 year (PhD) working experience is desirable.
  • Experience in cell culture.
  • Proficient in recombinant protein production/purification from E. coli, insect and mammalian expression systems.
  • Experience in protein crystallography and/or cryo-EM is desirable but not required. A strong motivation to keep abreast of new techniques is required.
  • Experience with biophysical/biochemical assays including thermal shift/direct binding assays is preferred.
  • Ability to work in a diverse team setting.
  • Excellent communication, interpersonal and organizational skills, including clear and consistent lab notebook-keeping.

Carmot offers competitive salary, 401K retirement plan with company contribution, participation in our stock option plan, and comprehensive benefits. This position is located onsite in Berkeley, CA. Must be authorized to work for any employer in the U.S.

Carmot Therapeutics, Inc. is committed to equal employment opportunity, regardless of age, ancestry, color, disability (mental and physical), exercising the right to family care and medical leave, gender, gender expression, gender identity, genetic information, marital status, medical condition, military or veteran status, national origin, political affiliation, race, religious creed, sex (includes pregnancy, childbirth, breastfeeding and related medical conditions), and sexual orientation.

The salary ranges for these positions are as follows:

Senior Research Associate: $105,000 - $175,000 annually

Scientist I: $100,000 - $170,000 annually