Scientist, Process Science at Senti Biosciences
South San Francisco, CA, US
Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.
At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.
Senti Bio is seeking an experienced scientist to join our process & analytical development group for our cell therapy programs. A successful applicant will have prior experience with process development and scale up of gene modified cell therapies, hands on experience taking a novel cell therapy through IND, and be comfortable in a fast moving and nimble culture. This role will be responsible to support pre-clinical activities including process optimization and pilot productions to identify key process parameters for new and existing products.  Applicants should have current and extensive knowledge of culture expanded allogeneic cell products (e.g. MSCs, NKs and T-cells), comfort with pre-clinical process development and GMP tech transfer to a CDMO, and familiarity with analytical methods development and implementation. We are seeking individuals who are passionate about the future of “smart therapeutics” and have the energy and boldness to thrive and grow in a dynamic and fast startup environment. 


    • Play a key role in process development for Senti's cell therapy development programs, with focus on process parameter optimization and verification, culture expanded allogeneic products, risk assessment and scale-up feasibility to meet milestones and timelines 
    • Design, perform and analyze complex multi-stage process parameters to identify critical process parameters for gene modification of NK cells and other therapeutic cell modalities
    • Work closely with the research teams to understand key requirements and guide early decision making to enable seamless transfers
    • Evaluate or identify new methods to monitor critical quality attributes of reagents and materials utilized in the cell engineering process
    • Evaluate or identify new technologies to streamline new development pipeline
    • Train and supervise junior staff in supporting CMC- related activities
    • Develop internal capability for larger scale bioreactor-based generation of genetically modified cells under quality-controlled conditions suitable for transfer to a GMP facility
    • Play a central role in selection and interaction with contract manufacturers, key suppliers, and other external vendors
    • Maintain thought leadership with the current cell therapy ecosystem and bring best practices to the organization
    • Coordinate tasks across multiple projects.
    • Make decisions on prioritization and planning
    • Be the key driver to meet project timelines and milestones
    • Present data to Process Development team, R&D, Tech Ops, and larger program-specific teams


    • BS/BA degree with 6+ years experience or MS/PhD degree with 4+ years experience in a cell therapy development setting.4+ years of cell therapy process development experience from proof-of-concept to clinical manufacturing, preferably with MSCs or MSC-like cells
    • Experience with lentiviral, retroviral, and other ex vivo cell engineering vectors a plus
    • Familiarity with IND regulatory requirements, GMP environments, and quality documentation
    • Strong organization skills and ability to multitask efficiently in a fast-paced setting
    • Strong communication, writing, and presentation skillsDemonstrated ability to work independently in a multi-functional project
Senti Bio is a leading gene circuit company designing gene circuits to create a new generation of “smarter medicines" and enhance the therapeutic effectiveness of cell and gene therapies against a broad range of diseases that are unaddressed by current standards of care. We are proud to count Leaps by Bayer, NEA, 8VC, Matrix Partners China, Mirae Asset Capital, Amgen Ventures, and others among our investors. In December 2021, Senti Bio and Dynamics Special Purpose Corp. (Nasdaq: DYNS), a special purpose acquisition company (SPAC), announced a definitive business combination agreement to create a public company focused on Gene Circuit-engineered cell and gene therapies. The transaction is expected to be completed in the second quarter of 2022. Senti Bio is based in South San Francisco, CA, USA.
We are committed to an inclusive and diverse Senti Bio. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse Senti Team. We welcome people of different backgrounds, experiences, abilities and perspectives and are an equal opportunity employer.