Associate Scientist/ Scientist I at RAPT Therapeutics
South San Francisco, CA, US

RAPT Therapeutics is a clinical stage immunology-based biopharmaceutical company focused on discovering, developing, and commercializing oral small molecule therapies for patients with significant unmet needs in oncology and inflammatory diseases. Utilizing its proprietary discovery and development engine, the Company is developing highly selective small molecules designed to modulate the critical immune drivers underlying these diseases. RAPT has discovered and advanced two unique drug candidates, FLX475 and RPT193, each targeting C-C motif chemokine receptor 4 (CCR4), for the treatment of cancer and inflammation, respectively. The Company is also pursuing a range of targets, including hematopoietic progenitor kinase 1 (HPK1) that are in the discovery stage of development.

 

We are seeking a highly motivated and creative scientist with expertise in tumor immunology to take a leading role in our internal research efforts to identify and develop cutting edge immune-based therapies for the treatment of cancer. The selected candidate will be part of the Discovery Biology Group evaluating the mechanism of action of our clinical targets including CCR4 inhibition for treatment of cancer and inflammatory diseases. Data generated will support ongoing clinical programs and help to establish rationale for indication selection.

 

ESSENTIAL DUTIES AND JOB FUNCTIONS:

  • Perform in vitro assays and in vivo modeling to evaluate the effect of candidate immunotherapies upon immune function in tumors and inflammatory diseases
  • Plan and execute in vivo tumor model studies to study the mechanism of novel immune-oncology agents
  • Participating in multidisciplinary team efforts to make key decisions on compound and program progression
  • Function as an integral to external collaborations with internal and external partners from the biology, DMPK & medicinal chemistry team
  • Presenting regular updates to project teams and the leadership team
  • Providing scientific guidance and technical advice to other team members
  • Representing the company by presenting and publishing innovative research

 

 

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • PhD or equivalent degree in immunology, cancer biology, pharmacology or relevant scientific discipline
  • Ideally 2 years post degree experience with proven successful research in industrial or academic settings or relevant graduate work
  • Extensive experience with cellular immunology and specifically in vivo tumor immunology or inflammation/allergy
  • Successful record of scientific publications and presentations
  • Excellent technical skills applicable to state-of-art research including being proficient in flow cytometry, primary culture, cell biology and functional analysis of immune cells
  • Experience with T cell functional assays
  • Experience with antigen specific immune cell assay is highly desired
  • Excellent problem-solving skills, applying scientific methods to resolution of critical issues
  • Excellent written and oral communication skills
  • Strong motivation, ability to work independently in a fast-pace multidisciplinary environment with minimal supervision
  • The candidate should also enjoy operating in an exceptionally dynamic, high-achieving and cooperative environment where every voice matters