Scientist, Protein Sciences at Surrozen
South San Francisco, CA, US

Surrozen is a biotechnology company focused on discovering and developing novel regenerative medicines with a focus on unlocking the powerful self-renewal properties of the body through specific control of the Wnt signaling pathway.

Surrozen was founded by five leading-edge scientists: K. Christopher Garcia, Ph.D., Roel Nusse, Ph.D. and Calvin Kuo, M.D., Ph.D. from Stanford University; Claudia Janda, Ph.D. from the Princess Maxima Center for Pediatric Oncology; and Hans Clevers, M.D, Ph.D. from the Hubrecht Institute and Princess Maxima Center. Each has conducted extensive research on Wnt signaling, with findings that together shape Surrozen’s technology and approach to therapeutic development.

We are seeking a talented and highly motivated protein chemist to join the Protein Sciences department to support discovery and pre-clinical therapeutic programs in a dynamic, team-oriented and collaborative environment. This role will work closely with molecular biology, small scale protein production, and other teams to express, purify and characterize mono- and bi-specific antibodies, as well as other novel protein formats, and contribute to Surrozen’s therapeutic pipeline. Exact title will be commensurate with experience.

 

Responsibilities

  • Support early discovery and preclinical development by providing protein and analytical expertise to advance pipeline projects
  • Develop and optimize methods, and perform protein expression, purification, biophysical, analytical and functional characterizations for various protein formats, including mono- and bispecific antibodies
  • Collaborate and contribute to interdisciplinary teams as a Protein Sciences representative
  • Maintain a detailed and well-organized record of experiments in an electronic notebook
  • Other duties as mutually agreed upon to make this position a career building experience

Requirements

  • Ph.D. in Biochemistry, Structural Biology, or related fields
  • Minimum 5-year experience in protein expression and purification
  • Demonstrated strong hands-on protein purification expertise and working knowledge of multiple classes of proteins on AKTA system (affinity capture, IEX, SEC, HIC). Experience with membrane protein is a plus
  • Familiar with different protein expression system including mammalian and insect expression systems
  • Experience with protein biochemical, biophysical (light scattering, thermal stability) and analytical (CE, HPLC) characterization techniques and their applications
  • Experience in protein modeling, structure-function analysis, and protein engineering is a plus
  • Excellent organizational and communication skills
  • Ability to work in fast paced environment and make contributions to multiple projects
  • Strong interpersonal skills and a team player committed to success and getting the job done well in a highly dynamic environment
  • Attention to detail, self-motivated

Benefits

  • We offer a dynamic start-up environment and a collaborative, passionate team
  • Excellent benefits, including competitive employer contributions
  • Stock options
  • Paid vacation, sick time and holidays
  • Shuttle service to/from Caltrain, BART and the South San Francisco Ferry
  • State-of-the-art research facility and onsite gym (see the amenities available at The Cove: http://leasing.covessf.com/toc.cfm)