Associate Director, Medicinal Chemistry at Circle Pharma
South San Francisco, CA, US
Circle Pharma is a pre-clinical stage, life sciences company discovering and developing macrocycle therapeutics, with an initial focus in oncology.  Our discovery platform allows us to address challenging therapeutic targets such as intracellular protein-protein interactions. 
Our structure-based drug discovery platform encompasses target affinity, cell permeability, medicinal chemistry and macrocycle synthesis, tightly integrated with biochemistry and cellular biology.  We have recently closed a $45M Series B round of funding, with investments from premier life science investors, The Column Group and Nextech Invest, and we are looking to expand our team. We seek candidates who desire to make key contributions to help drive our growth.  For more information about Circle Pharma,  please see our website,
In this newly created role, we are seeking a highly talented and motivated scientist to join our small molecule drug discovery team at the Associate Director level.  Our successful candidate will possess a deep passion for drug discovery, coupled with a track record of accomplishments and will play a key role in collaborating with the Circle team to build a pipeline of novel therapeutics, based on our macrocycle chemistry platform.

What You'll Do:

    • Establish project goals and scientific strategies while effectively driving the medicinal chemistry efforts to advance project goals, such as lead candidate selection
    • Closely follow emerging results of biological testing, ADME characterization, and other lead profiling assays
    • Conceive and execute new scientific strategies for the rapid optimization and improvement of key drug properties
    • Manage projects with CRO partners
    • Proactively gain market intelligence using available resources and incorporate this knowledge into our internal drug discovery programs
    • Regularly provide medicinal chemistry and project updates to a multidisciplinary drug discovery team, as well as to senior management
    • Maintain a high level of productivity in the laboratory as evidenced by consistently generating high-impact compounds
    • Lead and contribute to the writing of patent applications, study reports, and scientific publications

About You:

    • PhD in Organic Chemistry or equivalent, with 10+ years of medicinal chemistry experience in the biotechnology/pharmaceutical industry
    • Previous experience seeing a drug through to IND, required
    • Previous people management and project leading experience, required
    • Extensive knowledge of synthetic organic chemistry and superior problem-solving skills; experience in designing and executing multistep synthesis of complex organic molecules such as macrocycles, highly preferred
    • Experience using modern techniques in organic chemistry
    • Solid understanding and application of pharmacology, PK/PD, and ADME concepts
    • Ability to independently identify and promptly resolve core project challenges by effectively utilizing available information and scientific expertise
    • Demonstrated experience and success in lead optimization, structure-activity relationship analysis, and property-oriented drug design which has led to development candidate nomination
    • Knowledge and direct application of structure-based drug design computational tools to drive projects forward, required
    • Enthusiastic, high energy, and collaborative team player with strong ability to build productive relationships with scientists in the chemistry department as well as cross-functionally to enable high performance and team success
    • Exceptional oral communication and writing skills