Scientist I/II, In Vivo Pharmacology at Atreca
South San Francisco, CA, US

Atreca is an integrated biotechnology company located in South San Francisco, California (moving in 2021 to a new campus in San Carlos, CA). We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.

Position Summary

Atreca is looking for a talented and self-motivated Scientist to join its In Vivo Pharmacology team. The Scientist will apply his/her expertise to Atreca's oncology preclinical research program. The successful candidate will have the opportunity to interact and collaborate with a multidisciplinary team in a dynamic and fast paced scientific environment. In this role, the Scientist will oversee and perform multiple efficacy studies testing various therapeutic agents and combination regimens in mouse tumor models.

Duties and Responsibilities

This hands-on position requires strong scientific training and laboratory skills in the immunology, immuno-oncology, and oncology.

  • Design, conduct and interpret preclinical efficacy studies using mouse tumor models to test activity of drug candidates.
  • Develop and optimize in vivo mouse tumor models for use on Atreca's oncology program; assess and establish early PK for leads.
  • Work independently to perform and troubleshoot in vivo studies, and responsible for data collection, analysis, interpretation, and reporting. Also work collaboratively with scientists throughout the company to introduce and apply the most effective and efficient
  • technologies and techniques to expand our portfolio.
  • Literature research, academic collaborations, and innovative thinking are key components of such effort.
  • Prepare protocols and annual reports for IACUC revision or amendments.
  • Coordinate activities with functional and project team members, interface cross-functionally with other departments.
  • Effectively communicate and present study results both at internal team and departmental meetings and to external scientific
  • communities.

Required Skills and Qualifications

  • PhD with some postdoctoral experience in cancer biology, immunology or related field
  • 2-4 years of experience working in preclinical testing of anti-tumor drug candidates in mouse models Industrial experience is preferred.
  • Design and implement hypothesis-driven proposals to uncover potential new targets, uncover mechanism of action, advance pipeline.
  • Demonstrated proficiency with in vivo efficacy mouse models, including mouse syngeneic and xenograft models.
  • Hands-on experience with tumor cell inoculation, animal dosing via multiple routes, tissue collection, tumor measurements and data recording.
  • A demonstrated record of success in evaluating imaging methods/reagents is desired.
  • Practical experience with in vivo imaging techniques to investigate drug action and patho-physiological response is desired.
  • Able to follow protocols and SOPs and execute multiple simultaneous tasks independently. Proficiency in animal welfare and overall knowledge of federal guidelines for animal care and use.
  • Experience writing animal protocols and implementing new techniques.
  • Experience in providing management, mentoring, and training to research associates in all required animal research procedures.
  • Must demonstrate the ability to work independently and as well to work in small teams, ability to manage internal and external resources and collaborations.
  • Highly organized, detailed oriented and to have excellent communication. Proven leadership skills in mentoring and directing junior level research staff. The ability to work independently on research goals and to direct the research and day-to-day responsibilities of others.
  • Collaborative team player. Be flexible and prioritize tasks based on team and company goals. Ability to multitask in fast-paced environment.
  • Previous drug discovery experience, proficiency with GraphPad Prism, Excel, PowerPoint and Word preferred.

Exact title commensurate with experience. Atreca is an equal opportunity employer.