Carmot Therapeutics is a clinical stage biotechnology company dedicated to the discovery and development of innovative medicines for the treatment of metabolic diseases, cancer, and inflammation.  Carmot has developed a transformative drug discovery approach, Chemotype Evolution, that overcomes major limitations in existing drug discovery approaches and provides a unique opportunity to tackle challenging disease targets.  We have a broad metabolic pipeline and a portfolio of wholly-owned programs targeting class-B GPCRs and deubiquitinating enzymes, including our lead compound, CT-868, which is progressing toward Phase 2 clinical trials.  Carmot is seeking a dedicated and experienced in vivo pharmacologist with experience in metabolic disease models to help advance multiple discovery programs toward clinical development.

Position Summary:

In this position you will be responsible for designing and executing in vivo studies to expand Carmot’s internal pipeline.  You will be utilizing in vivo metabolic disease models for compound characterization and mechanism of action studies. These efforts will support lead discovery and translational biology for clinical compounds.  You will have the opportunity to lead new initiatives and impact programs from early discovery to through IND enabling studies.  Carmot is a dynamic and fast-paced environment with a strong culture of innovation, initiative and ownership. You must be excellent at balancing priorities and integrating into a multi-disciplinary team.

Primary responsibilities:

• Lead in-house and outsourced animal model studies to better understand MOA for Carmot’s clinical and pre-clinical metabolic disease programs
• Develop, conduct and troubleshoot animal efficacy studies to prioritize early lead compounds for further optimization
• Work closely with cell biology and lead discovery teams to design studies to differentiate and characterize lead compounds
• Effectively communicate results to team members and collaborators in chemistry and biology
• Identify new opportunities and initiatives and help drive innovation

Required experience and skills:

• PhD in cell biology or pharmacology with 1-4 years of industry experience
• Expertise with animal models in one or more of the following disease areas is essential:
• Liver disease, in particular NAFLD/NASH
• Metabolic syndrome research: appetite regulation, obesity, adipose tissue dysregulation and inflammation
• Diabetes related pathologies such as kidney failure, diabetic wound healing and tissue repair, neuropathy, retinopathy, and cardiovascular/microvascular disease
• Experience working with both biologics and small molecules and a clear understanding of appropriate PK/PD considerations for each
• Self-starter with ability to design and execute experiments independently
• Flexible work schedule with ability to contribute on evenings and weekends
• Ability to multitask and contribute to multiple projects and rapidly adapt to changing priorities
• Strong written and oral communication skills