Carmot Therapeutics is a clinical stage biotechnology company dedicated to the discovery and development of innovative medicines for the treatment of metabolic diseases, cancer, and inflammation. Carmot has developed a transformative drug discovery approach, Chemotype Evolution, that we apply to identify superior therapeutics internally and in collaboration with industry partners. Chemotype Evolution is a proprietary technology that overcomes major limitations in existing drug discovery approaches, providing us with a unique opportunity to tackle challenging disease targets. Our lead compound CT-868, a dual modulator of the GLP-1 and GIP receptors is progressing toward Phase 2 clinical trials and has the potential to be best in a new class of treatment for type 2 diabetes, obesity, and NASH. In addition, we have developed a broad metabolic pipeline and a portfolio of wholly-owned programs targeting class-B GPCRs and deubiquitinating enzymes that are progressing toward the clinic.
As a result of our strong scientific progress and clinical pipeline, we are seeking an ambitious and experienced pharmacologist with strong translational skills to lead our pharmacology group and translational science.
In this position, you will work closely with research and development teams to advance Carmot’s discovery and clinical programs. You will be directly responsible for leading the in vivo pharmacology team by designing and overseeing the execution of drug discovery studies using in vivo models of metabolic disease. An important part of this role includes the investigation of compound efficacy and mechanism of action and how these attributes translate to the clinical setting. You should have a deep understanding of metabolic disease models and their translational applicability to type 2 diabetes, obesity and NASH. Carmot is a dynamic and fast-paced environment with a can-do attitude and a strong culture of innovation, initiative and ownership. You must be excellent at multi-tasking and have the courage to push the boundaries and assume a broad array of responsibilities.
Required experience and skills:
Carmot offers competitive salary, participation in stock option plan, and comprehensive benefits. This position is at Carmot’s San Francisco site. We value diverse perspectives and encourage our scientists to contribute at multiple levels within the company. To apply, please forward your resume and contact information and include “dirpharm” in the subject line. Carmot is an equal opportunity employer.