Scientist, Protein Biochemistry at Atreca
South San Francisco, CA, US

Atreca is an integrated biotechnology company located in South San Francisco, California. We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing biotechnology company.

Position Summary

Atreca's IRC technology identifies anti-tumor human antibodies in a highly accurate and precise fashion. Our goal is to apply this technology to elucidate and characterize novel tumor targets and associated biologic processes that were selected for attack by the patient's immune system. In this position, the successful candidate will apply their skills and expertise in protein biochemistry to perform epitope characterization as related to tumor specificity of our novel targets. These will include characterizing tumor-specific post-translational modifications, complexes and expression. The successful candidate will have extensive experience in molecular biology and protein biochemistry and experience in optimizing conditions to move studies forward to reach project goals. As a successful candidate you will enjoy working in a fast-paced environment and collaborating across groups including in vivo pharmacology and translational sciences.

Duties and Responsibilities

  • Utilize expertise in protein biochemistry and immuno-oncology to identify and characterize tumor-specific alterations in proteins targeted by Atreca antibodies
  • Investigate tumor specific post-translation modifications and effects on antibody interaction using biochemical and molecular biology strategies
  • Perform mechanism of action studies, including studies conducted in coordination with translational sciences, in vitro and in vivo pharmacology teams
  • Manage one or more research associates
  • Manage projects with CRO’s as needed
  • Work with other project team members and communicate results with the team
  • Follow laboratory safety guidelines and practices

Required Skills and Qualifications

  • PhD with post-doctoral experience, preferably in immunology, tumor biology, cell biology or related field with a strong emphasis on protein biochemistry; 3-5 years of relevant industry experience preferred
  • Experience characterizing molecular mechanisms of tumorigenesis using protein biochemistry and/or molecular biology techniques
  • Experience in molecular biology and recombinant protein expression in eukaryotic systems a plus
  • Protein microarray experience highly desirable
  • Experience with lipid and/or carbohydrate biochemistry a plus
  • Experience managing research associates or technicians is required
  • Experience with tumor and tumor cell line transcriptome and/or proteome profiling is highly desirable
  • Must have excellent trouble-shooting, organization, and planning skills, and the ability to work under timeline in a fast-paced environment
  • Excellent written and oral communication skills

Exact title and salary commensurate with experience. Atreca is an equal opportunity employer.