Research Scientist - HTS Team at Notable Labs
Foster City, CA, US

Position Overview

We are seeking a hands-on, highly motivated, talented Research Scientist to join our High-Throughput Screening group.  This individual will focus on ex-vivo or in-vitro cell based assay development and optimization for drug candidate profiling and screening in support of Notable’s multiple projects. The candidate will serve as a team lead and provide expertise in identifying and implementing biological assays using our state of the art technology. He/she will be responsible for assisting in the design, development and optimization of our many external projects, including both our biotech and clinical partnerships, and development of continuous platform improvements.  Emphasis will be on helping to design and implement complex assays not currently run through our unique platform. The candidate should have a proven record of applying sound scientific judgement to answer critical questions, as well as a proven ability to design and implement appropriate experiments. Strong organizational skills and multi-tasking ability are required. The right candidate should also be very comfortable with working different types of automated high throughput equipment.  Ability to work independently in a high pace, multi-disciplinary environment is essential. Direct experience in hematology-oncology, drug discovery research and/or high-throughput screening strongly preferred.

What You Will Do

  • Design, develop, and optimize cell based plate assays to support external partnerships and drug discovery efforts
  • Assist in translation of external and internal projects onto our automated HTS platform, while effective working cross-functionally in a highly collaborative team environment
    • Communicate clearly and effectively both verbally and in writing
    • Maintain a cutting edge awareness of technical developments and scientific knowledge and apply these where possible to improve performance and data quality
    • Present results of work, interpret data, and draw conclusions in a fully independent manner.
    • Independently write scientific/technical reports and presentations
    • Must think critically and work resourcefully to resolve problems
  • Be very comfortable with automation and high throughput liquid handling instruments
  • Clearly present research updates to different project teams and across different company departments

What You Bring to the Role

  • PhD degree (5+ years industry exp) or MS/BS with (8+ years industry exp) in molecular cell biology, cancer biology, immunology, biochemistry or related field
  • Minimum of 3 years of flow cytometry experience
  • Industry experience in high throughput drug discovery and assay development preferred
  • Strong scientific foundation in the understanding and implementation of a wide range of cell-based and biochemical assays and readouts using state of the art technologies.
    • The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to solve research problems with experience in high throughput assays
  • FlowJo or Prism experience a plus
  • The candidate must be able to analyze and report data concisely and rigorously.
  • Adaptability and the ability to learn new techniques rapidly are essential.
  • Familiarity in the use of lab automation and HTS instrumentation is preferred.
  • Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results 

What we can offer you

  • The opportunity to directly fight cancer, one patient at a time
  • Exposure to experts from diverse backgrounds ranging from engineering, data science, operations, cancer biology, clinical medicine, patient advocacy, and beyond
  • Work in a collaborative environment with a team dedicated to both personal and scientific growth and development
  • Highly competitive, early stage company compensation package, with incredible growth opportunities
  • Outstanding healthcare benefits
  • Flexible vacation policy
  • … did we mention daily catered lunch?

More About Us

Notable Labs is a precision medicine company that has a translational drug discovery platform focused on identifying novel therapeutic options for cancer patients.

Our clinical research lab helps oncologists identify personalized and rational combinations of treatments for patients. We’ve developed a high throughput robotic flow cytometry lab platform that screens thousands of FDA-approved and investigational drug combinations against the patient’s own cancer cells to help predict safer and more effective cancer treatments. Our lab has completed initial feasibility studies with clinicians in relapsed Acute Myeloid Leukemia & Myelodysplastic Syndrome, with an 84% predictive rate. Focusing on individual patients and existing treatments, we’re working to discover novel uses of drugs and defining mechanisms underlying cancer progression and drug resistance.

Our research and development platform extends our clinical research to drug discovery, testing novel compounds with primary patient samples for pharmaceutical and biotechnology companies. Using our automated, high-throughput, multi-parametric drug screening research platform, industry partners can assay the biological impact of novel compounds on primary cells in a physiologically relevant environment. This helps our partners stratify patients by their predicted responsiveness, increasing the probability of successful clinical development. We are actively partnering with pharmaceutical companies that have preclinical and clinical stage drug pipelines in Acute Myeloid Leukemia, Myelodysplastic Syndrome, or related hematological malignancies to profile experimental drug activity in patient samples.

Our investors include Builders Venture Capital, Founders Fund, First Round Capital, Y Combinator, several prominent angels and seed-stage funds, and Accelerate Brain Cancer Cure, a venture philanthropy firm founded by Steve Case.

At Notable Labs we value diversity and are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.ᐧ