Scientist I, In Vivo Pharmacology – Discovery Biology at Nurix
San Francisco, CA, US
We are seeking a highly skilled and motivated in vivo pharmacologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The ideal candidate will have expertise in small molecule PK/PD studies in oncology and/or immuno-oncology.
This individual will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to evaluate PK/PD relationships, in vivo efficacy and ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.
Ph.D. in immunology, cancer biology or related field with 0-3 years of industry experience
Expertise in the in vivo evaluation of small molecules, PK/PD assay technologies, and hit-to-lead optimization required
In vivo pharmacology expertise with xenograft or syngeneic tumor models required
Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
Proven ability to manage junior scientists, external collaborations, and CROs
Experience with FACS-based characterization of immunity preferred
Novel in vivo model experience is a plus (e.g., CRISPR or humanized immune system mice)
Excellent communication and presentation skills
Excellent interpersonal skills and ability to work productively in a highly dynamic environment
Fit with Nurix Culture and Values
Team orientation; highly collaborative; solutions and results-oriented focus
Strong scientific curiosity and initiative; hands-on and resourceful
Self-driven and enthusiastic with the ability to thrive in a dynamic environment