Scientist - Immunology at Siolta Therapeutics
San Francisco, CA, US
Siolta Therapeutics is seeking highly ¬motivated and talented technical staff scientists to provide support for the company’s therapeutic development program focused on prevention/treatment of airway inflammation through manipulation of the gut microbiome. The successful candidate will work closely with other team members on preclinical studies of a rationally designed mixed-species therapeutic microbial consortium. The successful candidate will be technically proficient in immune cell culture/characterization, molecular techniques and experienced in animal handling.

Key Responsibilities:
• Design and develop preclinical murine models to demonstrate efficacy of microbial therapeutics
• Generate, analyze and interpret data from immunological assays in murine models of allergic inflammation
• Develop quantitative methods and analytical procedures for evaluating and interpreting immunological responses as they relate to inflammation and changes to the microbiome
• Maintain current awareness of literature, emerging approaches and methods at the intersection of immunology and microbiome sciences
• Contribute to the development of Siolta’s intellectual property estate

Essential Qualifications:
• Ph.D. in immunology, microbiology, or related fields
• Demonstrated success in project design, protocol development, and data analysis and interpretation
• Proficiency in immune cell characterization via flow cytometery (e.g., CYTOF)
• Experience in standard molecular and cellular assays used to evaluate host response e.g. qPCR/RT-PCR, ELISA and IHC
• Must be able to work both independently and collaboratively in fast¬ paced development environment
• Strong publication record

Preferred Qualifications:
• Experience with in vivo and/or in vitro cellular assays
• Experience with humanized, germ-free mouse models
• Participation in IND enabling studies
• Knowledge of microbiology