Scientist I, DNA Encoded Chemistry, Library Discovery at Nurix
San Francisco, CA, US
Position
We are seeking talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team. Specifically, this individual will join a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

Primary Functions

The successful candidate will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with aqueous chemistry and/or linker chemistry related to the synthesis of drug conjugates is highly preferred. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience.
Expert in synthetic organic chemistry methods and analytical tools.
High level of creativity and productivity with strong synthetic problem solving skills.
Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
Familiarity with principles of affinity selection, DNA encoded library technology, and/or SELEX
Experience Interest in developing novel chemical reactions and chemical library designs.
Experience with chemistry involving biological macromolecules, ie antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.