Scientist I, Affinity Selection Library Discovery at Nurix
San Francisco, CA, US
We are seeking a highly skilled and motivated Scientist with expertise in protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing mechanistic and structural insights to guide drug discovery efforts.

Primary Functions

The successful candidate will utilize DNA encoded libraries to identify novel, physiologically relevant chemical matter for a variety of targets within Nurix’s discovery pipeline. This person will also play a key role in discovery by evolving the standard paradigm of encoded library selection toward more extensive and mechanism-directed selection campaigns that exploit existing biophysical and mutation information. This individual will work closely with an interdisciplinary team of discovery scientists, all of whom have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.


Ph.D. in Biochemistry or related field with 0-3 years post-degree industry experience.
Expertise in DNA encoded library affinity selection or related methodologies (phage display or SELEX, etc…).
Experience in using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions.
Hands on experience performing biochemical assays.
Experience with protein expression and purification, ideally with multiprotein complexes.
A strong track record (publications or industry experience) with excellent interpersonal skills and ability to work in a team environment.
The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment.
Application Process Please include a two page research summary with your CV.