Senior Research Associate - Affinity Selection, Library Discovery at Nurix
San Francisco, CA, US
We are seeking a highly skilled and motivated Scientist with expertise in molecular biology, protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing mechanistic and structural insights to guide drug discovery efforts.
The successful candidate will have expertise in molecular biology and protein protein production, purification, and affinity selection and will play a key role in utilizing DNA encoded libraries to identify novel, physiologically relevant chemical matter in accord with Nurix’s biophysical and structural expertise in the UPS space. This person will work directly with our existing biochemists and biologists to develop selection strategies and tools to enable library interrogation. This individual will be a member of a small team, working closely with several experienced groups of interdisciplinary scientists all of whom have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.
Masters in Biochemistry, Cell and Molecular Biology, or related field with 4+ years post-degree industry experience.
Expertise in a range of biochemical and cell-based assay methodologies.
Experience with protein production in bacterial, baculovirus and mammalian expression systems, familiarity with multiprotein complexes a plus.
Knowledge of expression platforms, purification systems and analytical techniques (e.g. Wave bioreactor, AKTA, HPLC/MS, TFF).
Familiarity with higher throughput methodologies for protein purification and affinity selection.
Experience with sample production and QC for capillary and NGS sequencing platforms.
A strong track record (publications, industry experience) with excellent interpersonal skills and ability to work in a team environment.
The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment