SCIENTIST II/SENIOR SCIENTIST, IN VIVO PHARMACOLOGY, DISCOVERY BIOLOGY at Nurix
San Francisco, CA, US
We are seeking a highly skilled and motivated in vivo pharmacologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.

Primary Functions
The ideal candidate will have expertise in small molecule PK/PD studies in oncology and/or inflammation. The Scientist II/Senior Scientist of In Vivo Pharmacology will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to evaluate PK/PD relationships, in vivo efficacy and ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

Ph.D. in immunology, cancer biology or related field with 8+ years of industry experience in pharmacology for Senior Scientist or 4+ years for Scientist II
In Vivo pharmacology expertise with animal models of human cancers and inflammation
Expertise in formulation of small molecules and PK/PD assay technologies required
Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
Expertise in FACS-based phenotypic and/or functional characterization of immunity
Expertise in novel in vivo technologies is a plus (e.g., CRISPR or humanized immune system mice)
Proven ability to manage junior scientists, external collaborations and CROs preferred
Excellent communication and presentation skills
Experience in preparing IND documents
Excellent interpersonal skills and ability to work productively in a highly dynamic environment