Clinical Laboratory Scientist (CLS) at Notable Labs
San Francisco, CA, US
Changing the way cancer is treated is our personal mission, which starts with putting patients first. We’ve developed an individualized laboratory testing service for cancer patients and their doctors. We screen thousands of FDA-approved drugs against the patients own cancer cells to identify drug combinations that can be immediately prescribed by their doctor without a clinical trial. By repositioning treatment as a patient-centered service we can unlock the power of modern data science and laboratory automation to achieve the promise of combination therapy and personalized medicine.

Our investors include Founders Fund, First Round Capital, Y Combinator, several prominent angels and seed-stage funds, and Accelerate Brain Cancer Cure, a non-profit founded by Steve Case. We have offices and a laboratory in San Francisco’s SoMa district.

Technology:

We’ve developed a high throughput robotic testing platform that uses a patient’s live tumor cells to predict the safest and most effective treatment combinations. We employ an ex vivo assay to survey thousands of drug combination options. To ensure our translational system is predictive we’ve created a proprietary method to mimic the microenvironment of the human body. Our drug panel includes all approved chemotherapies and targeted agents, as well as generic non-oncology drugs that have published anti-neoplastic evidence.

We prioritize the safest combinations from our viability assay by estimating a therapeutic index. Successful hits are counter-screened against normal human cells to determine a customized, relative drug scoring system for each patient. The end result of our process is a CLIA certified report which prioritizes therapeutic options that could be used by the physician and patient.

Position Overview:

We're looking for an experienced, licensed Clinical Laboratory Scientist to join our CLIA laboratory team. This individual will report to the CLIA Laboratory Director, but would also interface with the Research and Development as well as Engineering teams.
RESPONSIBILITIES

Performing high complexity testing on clinical specimens, with a focus on determining tumor sensitivity and resistance to drug combinations
Develop, execute, and improve the laboratory's standard operating procedures for specimen handling, reagent preparation, processing, test analyses, recording of test results, and environmental/health safety
Performing, reviewing, and documenting laboratory quality control procedures and training
Independently identifying and troubleshooting issues that could adversely affect test performance
Documenting all corrective actions taken when test systems deviate from the laboratory's established performance specifications
QUALIFICATIONS

Compassion for cancer patients and passion for reinventing cancer treatment
A current California Clinical Laboratory Scientist (CLS) license (generalist, clinical chemist, or clinical hematologist scientist)
Laboratory experience in clinical chemistry, hematology, cytology, cell-based assays, or other equivalent clinical laboratory testing areas
B.A, B.S., M.A. or M.S. in chemical, physical, biological science, or medical technology
Self-starting, flexible mindset
Ability to work independently with a multi-disciplinary engineering team in a resourceful startup
BONUS

Experience with automation and high throughput screening assays
Mammalian cell culture experience
Novel assay design and development