Research Associate/Sr. Research Associate, CAR T Cell Therapy at Senti Biosciences
South San Francisco, CA, US
Thank you for your interest in a career at Senti Biosciences. We are seeking individuals who are passionate about the future of genetic circuit therapeutics and have the energy and boldness to thrive and grow in a dynamic and fast entrepreneurial environment.
 
Senti Biosciences is seeking an experienced, talented, and driven biologist to join our growing CAR T cell team to execute key experiments towards developing next-generation cell therapies for cancer.  The successful candidate will be comfortable performing in vitro experiments and working collaboratively across various project teams to meet deadline-dependent milestones.  Prior experience with primary human T cell isolation and handling, complex cell co-culture experiments, and functional assays is highly desirable.

Responsibilities

    • Work with scientists to engineer and expand primary human T cells for in vitro functional assays.
    • Assist in functional screens to optimize human T cell function, efficacy, and safety.
    • Engineer and maintain human cancer cell lines.
    • BSL2 lentivirus and cell culture work
    • Assist in drafting experimental protocols, maintaining detailed lab records, and performing data analysis.  Data presentation opportunities are available.

Qualifications

    • Bachelor’s or Master’s degree in biology-related field required; degree in Immunology, Cell Biology, Cancer Biology, or Gene Therapy preferred.
    • 4+ years of research experience in a biology laboratory setting, industry experience is a plus.
    • Hands-on proficiency with sterile cell culture techniques, preferably including experience with T cells and/or other hematopoietic cell populations.  T cell-based assays measuring cell proliferation, cytotoxicity, and cytokine production, a plus.
    • Multicolor flow cytometry and FlowJo-based data analysis.
    • Demonstrated ability to work independently and as part of a multi-functional team.
    • Excited by the challenge of working in a dynamic, flexible, and fast-paced environment
    • Preferred qualifications include: A cancer or hematopoietic cell background, experience with chimeric antigen receptors (CARs), lentivirus generation, hematopoietic cell transduction, ELISA/Luminex, Incucyte, and previous immunohistochemistry experience.
    • You are motivated, detail-orientated, and eager to be part of a positive work environment with other researchers to develop much needed novel cell therapies targeting cancer.
Compensation and title commensurate with qualifications and experience. Significant growth opportunity as the company expands.
 
Senti Bio is the next generation therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value. Our mission is to engineer an entirely new class of medicine that will transform people’s lives by curing the most challenging diseases. We are proud to count NEA, 8VC, Amgen Ventures, Pear Ventures, Lux Capital, Menlo Ventures, Allen & Company, Nest.Bio, Omega Funds, Goodman Capital, and LifeForce Capital among their investors. Senti Bio is based in South San Francisco, CA, USA.