Scientist, Process Development at Senti Biosciences
South San Francisco, CA, US
Thank you for your interest in a career at Senti Biosciences. We are seeking individuals who are passionate about the future of genetic circuit therapeutics and have the energy and boldness to thrive and grow in a dynamic and fast entrepreneurial environment.
Senti Bio is seeking an experienced scientist to join our process & analytical development group for our cell therapy programs. A successful applicant will have prior experience with process development and scale up of gene modified cell therapies, hands on experience taking a novel cell therapy through IND, and be comfortable in a fast moving and nimble culture. Applicants should have current and extensive knowledge of culture expanded allogeneic cell products (e.g. MSCs), comfort with pre-clinical process development and GMP tech transfer to a CDMO, and familiarity with analytical methods development and implementation. We are seeking individuals who are passionate about the future of “smart therapeutics” and have the energy and boldness to thrive and grow in a dynamic and fast startup environment. 


    • Play a key role in process development for Senti's cell therapy development programs, with focus on culture expanded allogeneic products, including mesenchymal stromal cells (MSCs) and other therapeutic cell modalities.
    • Work closely with the research team to understand key requirements and guide early decision making to enable seamless transfers.
    • Develop internal capability for larger scale bioreactor-based generation of genetically modified cells under quality-controlled conditions suitable for transfer to a GMP facility. 
    • Play a central role in selection and interaction with contract manufacturers, key suppliers, and other external vendors.
    • Maintain thought leadership with the current cell therapy ecosystem and bring best practices to the organization.
    • Coordinate tasks across multiple projects. Make decisions on prioritization and planning. Be the key driver to meet project timelines and milestones.


    • BS/BA degree with 6+ years experience or MS/PhD degree with 4+ years experience in a cell therapy development setting.
    • 4+ years of cell therapy process development experience from proof-of-concept to clinical manufacturing, preferably with MSCs or MSC-like cells.
    • Experience with lentiviral, retroviral, and other ex vivo cell engineering vectors a plus.
    • Familiarity with IND regulatory requirements, GMP environments, and quality documentation.
    • Demonstrated ability to work independently in a multi-functional project at a fast moving organization.
Senti Bio is the next generation therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value. Our mission is to engineer an entirely new class of medicine that will transform people’s lives by curing the most challenging diseases. We are proud to count NEA, 8VC, Amgen Ventures, Pear Ventures, Lux Capital, Menlo Ventures, Allen & Company, Nest.Bio, Omega Funds, Goodman Capital, and LifeForce Capital among their investors. Senti Bio is based in South San Francisco, CA, USA.